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. 2021 Apr 7;592(7853):253–257. doi: 10.1038/s41586-021-03335-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, The proportion of Neanderthal ancestry in Bacho Kiro Cave individuals and other ancient and present-day modern humans calculated with a direct f₄ ratio that takes advantage of the two high-coverage Neanderthal genomes^9,10,41. f₄ ratio (alpha) values calculated using ADMIXTOOLS²⁸ as implemented in admixr⁶¹. b, c, Neanderthals^9,10,42 share significantly more derived alleles with the IUP Bacho Kiro Cave individuals than with most present-day³¹ (b) or ancient modern humans (c). D values calculated using ADMIXTOOLS²⁸ as implemented in admixr⁶¹. Filled circles correspond to |Z| ≥ 3; open circles indicate |Z| < 3 (not significant). Error bars in all panels show s.e. calculated using a weighted block jackknife²⁸ across all autosomes on the 2200k Panel (nsnps = 2,056,573) and a block size of 5 Mb.