Table 1.
Demographic and baseline data of the CYCLE-HD cohort
| Baseline data of CYCLE-HD cohort n = 130 [Nmiss] | |
|---|---|
| Age (years) | 57.2 ± 15 |
| Male, n (%) | 95 (73%) |
| Ethnicity, n (%) | |
| White | 58 (45%) |
| BAME | 72 (55%) |
| SBP (mmHg) | 143 ± 22 |
| DBP (mmHg) | 76 ± 14 |
| Dialysis vintage (years) | 1.3 (0.5, 3.4) |
| Haemoglobin (g/L) | 111 ± 17 |
| Albumin (g/L) | 36.9 ± 5 |
| CRP (mg/L) | 14.0 (8, 34) |
| Total Cholesterol (mmol/L) | 4.0 ± 1.4 [28] |
| Triglycerides (mmol/L) | 1.93 ± 1.39 [47] |
| HbA1c (%) | 5.7 (5, 7) [38] |
| BMI (kg/m2) | 27 (23, 31) |
| Co-morbidities | |
| Ischaemic heart disease, n (%) | 16 (12%) [1] |
| Hypertension, n (%) | 86 (67%) [1] |
| Diabetes mellitus, n (%) | 49 (38%) [1] |
| Atrial Fibrillation, n (%) | 5 (4%) [1] |
| Previous renal transplant, n (%) | 20 (15%) |
| CMR measures of cardiovascular disease | |
| LVMi (g/m2) | 60 (50, 76) |
| LV ejection fraction (%) | 53.6 ± 10 |
| LV mass/LV end-diastolic volume (g/mL) | 0.73 ± 0.2 |
| Global Native T1 (ms) | 1273.6 ± 40.8 [6] |
| Global longitudinal strain (%) | − 13.2 ± 3.3 |
| PWV (m/s) | 8.2 (6, 11) [13] |
| Humoral markers of cardiovascular disease | |
| NT pro-BNP (pg/ml) | 2693 (1136, 10121) [10] |
| Troponin I (ng/L) | 10.1 (6, 17) [6] |
| Baseline physical performance in field tests | |
| ISWT (m) | 220 (140, 360) [16]a |
| STS60 (reps) | 16.1 ± 11.5 [13]a |
[Nmiss] number of missing data values. Normally distributed data presented as mean ± SD, non-normally distributed data presented as median (25th, 75th percentile). LV indices indexed to body surface area
BAME Black, Asian and minority ethnic, SBP systolic blood pressure, DBP diastolic blood pressure, CRP C-reactive protein, BMI body mass index, LV left ventricle, LVMi left ventricular mass index, PWV pulse wave velocity
aThe missing data for the physical function tests limited the numbers that could be included in univariate and multivariate regression models.