Table 4.

Predictors of events accuracy (ROC curve analysis)

	AUC	95% CI	p	Youden index	Criterion	Sensitivity %	Specificity %
Age (years)	0.767	0.669–0.847	0.0001	0.4460	> 49	71.4	73.2
Male sex	0.620	0.515–0.717	0.0942	0.2404	+	64.3	59.8
eGFR (mL/min/1.73 m2)	0.749	0.650–0.832	0.0003	0.4007	≤ 69.0	57.1	82.9
hs-TnI (pg/mL)	0.878	0.795– 0.936	< 0.0001	0.7596	> 8.0	85.7	90.2
NT-proBNP (pg/mL)	0.834	0.744–0.902	< 0.0001	0.5906	> 158	78.6	80.5
LV hypertrophy	0.830	0.745–0.915	< 0.0001	0.6603	+	92.9	73.2
LV mass index (g/m2.7)	0.872	0.744–1.000	< 0.0001	0.7700	> 54.3	92.9	84.1
Left atrium volume (mL/m2)	0.909	0.819–0.999	< 0.0001	0.7247	> 43	78.6	93.9
E/Ea	0.925	0.845–1.000	< 0.0001	0.8084	> 12.8	85.7	95.1
LV ejection fraction (%)	0.708	0.512–0.904	0.0372	0.4617	≤ 57	57.1	89.0
GLS (%)	0.848	0.756–0.940	< 0.0001	0.5767	> -15.5	85.7	71.9
MEE index (mL/s per g)	0.858	0.740–0.977	< 0.0001	0.6969	≤ 0.26	92.9	76.8
GWI (mmHg%)	0.892	0.766- 1.000	< 0.0001	0.7247	≤ 1148	78.6	93.9
GCW (mmHg%)	0.908	0.797–1.000	< 0.0001	0.7944	≤ 1513	92.9	86.6
GWW (mmHg%)	0.812	0.697–0.928	< 0.0001	0.4669	> 83	85.7	61.0
GWE (%)	0.915	0.830–1.000	< 0.0001	0.7108	≤ 91	85.7	85.4

ROC receiver operating characteristic, AUC area underthecurve, CI confidence interval, eGFR estimated glomerular filtration rate, hs-TnI high-sensitivity troponin I, NT-proBNP N-terminal prohormone of Brain Natriuretic Peptide, LV left ventricular, E/Ea ratio the ratio of mitral (E) to mitral annulus (Ea) early diastolic peak velocity, MEE mechano-energetic efficiency, GWE global work efficiency, GWI global work index, GCW global constructive work, GWW global wasted work