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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2021 Jan 5;20(4):632–640. doi: 10.1158/1535-7163.MCT-20-0741

Table 1.

Proteins directly or indirectly regulated by PLK4 that are essential to the centriole duplication process.

Protein(s) Interaction Function Reference(s)
CEP63 Complexes with CEP152

  • Localizes CEP152

  • Aids in efficient centriole duplication

  • Regulates CDK1 localization to centrosome

 (67,68)
CEP85 Binds to STIL

  • Implicated in directional cancer and cell migration

  • Regulates PLK4 activity

 (24,69)
CEP131 Phosphorylated by PLK4

  • Enhance PLK4 activation and centriole duplication

  • Centriolar satellite protein vital to genomic stability

 (46,47)
CEP135 Binds to CPAP

  • Procentriole formation and elongation

 (70)
CEP152 CEP192 Bind to PLK4

  • Recruit PLK4 to parent centriole during G1

 (71)
SAS-6 Binds to STIL after phosphorylation of STIL by PLK4

  • Initiates and organizes the assembly of the central cartwheel

 (21)
STIL Binds to PLK4

  • Promotes activation of kinase dimers

  • Centriole duplication

  • Link procentriole cartwheel to microtubule wall

 (21,72)
CENPJ/CPAP Interacts with centriole proteins and binds STIL

  • Molecular link between cartwheel and triplet microtubule

  • Controls centriole length

  • Recruits PCM

  • Procentriole formation and stabilization

  • Regulate length of centriole

 (21,73)
FBXW5 Phosphorylated by PLK4 to suppress ability to ubiquitylate SAS-6

  • Control centrosome duplication and number

 (74,75)