Table 1 –
protein-coding genes significantly downregulated by both inhibitor treatment and PPARG KO by sgRNA 6
| Ensembl Stable ID | Gene name | CTT_v_CTD log2FoldChange | CTT_v_CTD padj | CR6_v_CTD log2FoldChange | CR6_v_CTD padj | CR9_v_CTD log2FoldChange | CR9_v_CTD padj |
|---|---|---|---|---|---|---|---|
| ENSG00000099194 | SCD | −1.84836 | 4.75E-32 | −0.967383 | 1.31E-08 | −0.752986 | 3.78E-05 |
| ENSG00000164687 | FABP5 | −0.99932 | 4.64E-22 | −0.643733 | 6.05E-09 | −0.495873 | 2.96E-05 |
| ENSG00000112769 | LAMA4 | −1.61257 | 4.18E-35 | −1.02366 | 5.47E-14 | −0.627017 | 3.51E-05 |
| ENSG00000152661 | GJA1 | −1.07888 | 2.00E-35 | −0.964049 | 5.57E-28 | −0.699964 | 1.50E-14 |
| ENSG00000147872 | PLIN2 | −1.81531 | 1.33E-71 | −0.719112 | 1.49E-11 | −0.346714 | 0.008121 |
| ENSG00000175445 | LPL | −0.689581 | 0.000155974 | −0.642038 | 0.00112915 | −0.507711 | 0.0223404 |
| ENSG00000145819 | ARHGAP26 | −0.974373 | 2.95E-06 | −0.699078 | 0.00319829 | −0.338475 | 0.346469 |
| ENSG00000139668 | WDFY2 | −1.10349 | 0.000942173 | −0.882333 | 0.0209325 | −0.44463 | 0.450809 |
| ENSG00000166582 | CENPV | −1.09435 | 3.02E-13 | −0.723569 | 9.47E-06 | −0.471268 | 0.0148911 |
| ENSG00000272410 | AC022384.1 | −0.733766 | 0.029615 | −1.26105 | 5.31E-05 | −0.406835 | 0.459134 |
| ENSG00000164690 | SHH | −3.85968 | 8.48E-10 | −1.70939 | 0.0220824 | −1.21403 | 0.199725 |
| ENSG00000186205 | MARC1 | −0.872443 | 2.55E-05 | −0.67909 | 0.00324381 | −0.579206 | 0.0234548 |
| ENSG00000270885 | RASL10B | −0.980824 | 0.00119155 | −1.01761 | 0.00131968 | −0.406437 | 0.436146 |
| ENSG00000196636 | SDHAF3 | −0.81483 | 0.00725144 | −0.748726 | 0.0259025 | −0.16698 | 0.825209 |
| ENSG00000162769 | FLVCR1 | −0.598071 | 0.0041765 | −0.606917 | 0.00618048 | −0.15439 | 0.747874 |
| ENSG00000088280 | ASAP3 | −0.752019 | 0.0467213 | −0.905955 | 0.0207149 | −0.362481 | 0.589076 |
| ENSG00000187772 | LIN28B | −1.18362 | 4.01E-12 | −0.698968 | 0.000145048 | −0.354951 | 0.155858 |
| ENSG00000107614 | TRDMT1 | −0.802833 | 0.0411313 | −0.930975 | 0.0236378 | −0.00304135 | 0.997887 |
| ENSG00000185306 | C12orf56 | −0.98203 | 0.000131536 | −0.688257 | 0.0220165 | −0.673972 | 0.0349877 |
| ENSG00000056277 | ZNF280C | −0.661477 | 0.0299821 | −0.726138 | 0.0259025 | −0.370599 | 0.45078 |
| ENSG00000126562 | WNK4 | −1.33002 | 2.29E-08 | −1.05148 | 1.72E-05 | −0.563283 | 0.0770588 |
| ENSG00000107295 | SH3GL2 | −1.52589 | 4.99E-06 | −1.25267 | 0.000556914 | −0.989043 | 0.0159139 |
| ENSG00000176532 | PRR15 | −1.768 | 4.23E-11 | −0.967951 | 0.000823952 | −0.848442 | 0.00536503 |
| ENSG00000137819 | PAQR5 | −0.896192 | 0.0303572 | −0.992695 | 0.0215294 | −0.798751 | 0.115044 |
| ENSG00000007944 | MYLIP | −0.669156 | 0.0307392 | −0.925459 | 0.00324381 | −0.374242 | 0.449459 |
| ENSG00000123576 | ESX1 | −2.43788 | 7.88E-15 | −0.878463 | 0.00763728 | −0.740077 | 0.0428575 |
| ENSG00000198691 | ABCA4 | −2.34148 | 0.0153891 | −2.67712 | 0.0112151 | −5.37503 | 1.70E-07 |
| ENSG00000100433 | KCNK10 | −3.23619 | 0.00525737 | −3.05194 | 0.00622587 | −3.73567 | 0.000766383 |
| ENSG00000257446 | ZNF878 | −1.10965 | 0.0307597 | −1.31489 | 0.0164442 | −0.776613 | 0.279924 |
| ENSG00000068976 | PYGM | −2.27423 | 0.000138108 | −2.30913 | 0.00023289 | −2.65603 | 3.46E-05 |
Denotes significant positive association with PPARG mRNA expression in primary samples
CTD - Control gRNA, DMSO
CTT - Control gRNA, 100 nM T0070907
CR6 - PPARG sgRNA 6
CR9 - PPARG sgRNA 9