Figure 2:

Early after-depolarizations (EADs) depend on cleft width and cell size. (A) Transmembrane voltage (V_m), (B) Na⁺ current at the ID $\left(I_{Na}^{\mathit{\text{disc}}}\right)$, (C) Na⁺ channel open probability at the ID $\left(p_{Na}^{\mathit{\text{open}}}\right)$, (D) cleft Na⁺ concentration ([Na⁺]_cleft), and (D) the Na⁺ reversal potential at the ID $\left(E_{Na}^{\mathit{\text{disc}}}\right)$ are shown in mutant tissue for narrow (left) and wide (right) intercellular cleft widths (w). Traces for wild-type (WT) are shown for 100% cell size for comparison (black lines). For clarity, traces are shown for cell 25 out of 50 in the one-dimensional chain of cells. Parameters: BCL = 1000 ms, ID_Na = 50%, ρ_Na = 100%, f_gap = 100%.