Figure 3:

Action potential duration (APD) prolongation due to increased cell size and Na⁺ channel density in mutant tissue. APD is shown as a function of cell size (S) for different values of Na⁺ channel density (ρ_Na) for 10% (left column), 50% (middle column), and 90% (right column) Na⁺ channel ID localization (ID_Na) for intercellular cleft widths of w = 10 nm (top row), w = 20 nm (middle row), and w = 40 nm (bottom row). APD for wild-type (WT) is shown for 100% ρ_Na for comparison (black lines). Parameters: BCL = 1000 ms, f_gap = 100%. Parameter regimes associated with neonatal (gray boxes) and adult (black boxes) tissue are highlighted.