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Action potential duration (APD) prolongation is suppressed at shorter cycle lengths and promoted at longer cycle lengths in mutant tissue. APD is shown as a function of cell size (S) for different values of Na+ channel density (ρNa) for 10% (left column), 50% (middle column), and 90% (right column) Na+ channel ID localization (IDNa). APD for wild-type (WT) is shown for 100% ρNa for comparison (black lines). Parameters: (A) BCL = 500 and (B) 2000 ms, cleft width w = 40 nm, fgap = 100%.
