Figure 1.

N-terminal amino acid sequences of hUNG1 nuclear and mitochondrial variants and hUNG2. Binding motifs are shown in yellow and labeled with their respective interacting proteins, i.e. proliferating cell nuclear antigen (PCNA) and replication protein A (RPA). Isoform-specific residues are shown under brackets. The primary mitochondrial processing peptidase (MPP) cleavage sites is denoted between residues 29 and 30, and minor MPP cleavage sites are shown between residues 75 and 76 and 77 and 78. Conserved catalytic domain residues are labeled as CD at the C-terminus. Post-translational modifications (obtained from Hornbeck et al. 2015 and Bao et al. 2020) are shown above corresponding residues with the following labels: red as acetylation, orange as ubiquitylation, and blue as phosphorylation.