Table 4.
HRs for overall mortality by diabetes duration at CRC diagnosis, stratified by follow-up period after diagnosis.
| Overall mortality | Women | Men | ||||
|---|---|---|---|---|---|---|
| No diabetes | ≤10-year diabetes | >10-year diabetes | No diabetes | ≤10-year diabetes | >10-year diabetes | |
| No. of patients | 2349 | 148 | 136 | 1260 | 82 | 63 |
| Median overall survival, years | 11.1 | 10.0 | 4.3 | 8.8 | 10.4 | 5.2 |
| % alive at 5 years | 63.0 | 62.1 | 45.4 | 61.8 | 71.6 | 53.3 |
| Follow-up period | ||||||
| ≤5 years | ||||||
| No. of deaths | 845 | 53 | 69 | 467 | 23 | 28 |
| Age-adjusted HR (95% CI) | 1 | 1.00 (0.75–1.31) | 1.42 (1.11–1.81) | 1 | 0.63 (0.42–0.96) | 0.97 (0.66–1.43) |
| Multivariate HR (95% CI)a | 1 | 1.10 (0.83–1.45) | 1.39 (1.09–1.78) | 1 | 0.74 (0.48–1.12) | 1.00 (0.67–1.47) |
| Multivariate HR (95% CI)b | 1 | 1.06 (0.79–1.40) | 1.39 (1.08–1.78) | 1 | 0.72 (0.47–1.10) | 0.96 (0.65–1.41) |
| >5 to 10 years | ||||||
| No. of deaths | 229 | 14 | 17 | 159 | 14 | 10 |
| Age-adjusted HR (95% CI) | 1 | 1.11 (0.65–1.91) | 2.36 (1.44–3.87) | 1 | 1.15 (0.67–1.99) | 1.63 (0.86–3.10) |
| Multivariate HR (95% CI)a | 1 | 1.12 (0.65–1.92) | 2.41 (1.47–3.95) | 1 | 1.19 (0.69–2.07) | 1.51 (0.78–2.91) |
| Multivariate HR (95% CI)b | 1 | 1.12 (0.65–1.93) | 2.30 (1.39–3.78) | 1 | 1.17 (0.67–2.03) | 1.48 (0.77–2.86) |
| >10 years | ||||||
| No. of deaths | 286 | 24 | 11 | 177 | 13 | 1 |
| Age-adjusted HR (95% CI) | 1 | 2.32 (1.52–3.52) | 4.04 (2.20–7.42) | 1 | 2.41 (1.37–4.26) | NAc |
| Multivariate HR (95% CI)a | 1 | 2.37 (1.55–3.61) | 4.01 (2.18–7.40) | 1 | 2.46 (1.37–4.41) | NAc |
| Multivariate HR (95% CI)b | 1 | 2.40 (1.57–3.67) | 4.21 (2.27–7.79) | 1 | 2.41 (1.34–4.32) | NAc |
Abbreviation: NA, not available.
Stratified by cancer stage (I to IV or unknown) and adjusted for age at cancer diagnosis (continuous), race (White, nonwhite, or unknown), grade of tumor differentiation (well differentiated, moderately differentiated, poorly differentiated, or unknown), location of primary tumor (proximal colon, distal colon, rectum, or unknown), and year of diagnosis (continuous).
Additionally adjusted for body mass index (continuous), physical activity (continuous), smoking status (never, past, or current), alcohol intake (continuous), AHEI-2010 (continuous), and regular aspirin use (yes or no).
HRs not shown due to the small number of patients in the risk set (n = 6).