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. Author manuscript; available in PMC: 2021 Sep 5.
Published in final edited form as: Oncogene. 2021 Mar 5;40(13):2448–2462. doi: 10.1038/s41388-021-01683-y

Fig. 3. PSPH loss results in widespread changes in metabolic pathways.

Fig. 3.

a. Heatmap showing the metabolite profile of A375 cells expressing PSPH shRNAs or a nonspecific (NS) control shRNA. b. Pathway enrichment analysis showing the top 50 metabolic pathways altered in A375 cells expressing PSPH shRNAs or a nonspecific (NS) shRNA using the MetaboAnalyst metabolic pathway analysis tool. c. Plot showing the calculated metabolic pathway impact score and relative log(p)-values of metabolic pathways altered in A375 cells as a result of shRNA-mediated PSPH knockdown. The indicated metabolic pathways associated with different metabolic processes using MetaboAnalyst, a metabolomics tool for pathway analysis and visualization.