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. Author manuscript; available in PMC: 2021 Sep 5.
Published in final edited form as: Oncogene. 2021 Mar 5;40(13):2448–2462. doi: 10.1038/s41388-021-01683-y

Fig. 8. Model.

Fig. 8.

A model showing the mechanism by which PSPH facilitates melanoma tumor growth and metastasis. We find that PSPH promotes melanoma tumor growth and metastasis by regulating the activity of DNA and histone demethylases (e.g., TET and JMJD/KDM) by repressing the levels of 2-HG and by activating tumor-promoting pathways and expression of NR4A1 and other genes.