Fig. 1.

This figure illustrates the interaction between B-cells and T-cells. Follicular T-helper (T_fh) cells and regulatory T-cells (T_regs) can promote and inhibit immune response, respectively. The B cell lymphoma 6 (BCL-6) protein potentially binds to the miR-142-3p/5p promoter region and suppresses miR-142-3p/5p expression, which in turn enhances the expression of costimulatory molecules (CD40L, ICOS, and CD84) and cytokines (IL-4, IL-10, and IL-21) by T-cells, increases IgG production by B cells, and modulates the suppressive function of T_regs