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. 2021 Apr 7;12(4):379. doi: 10.1038/s41419-021-03651-6

Fig. 2. Genetic inactivation of RIP1 kinase activity ameliorates neurological function following ischemic brain injury.

Fig. 2

A Experimental timeline and endpoints in the tMCAO model. B Body weights of WT and RIP1 KD rats before and after sham or tMCAO surgery. C–F Behavioral scoring of WT and RIP1 KD rats before and after sham or tMCAO surgery. 20-point neuroscore (C), limb placing (D), and beam walking (forepaw (E) and hindpaw (F)) tests were performed. n = 8–10 rats/group. At the indicated time points, **p < 0.01 between WT-tMCAO and WT-Sham (in gray), and *p < 0.05 and **p < 0.01 between RIP1 KD-tMCAO and WT-tMCAO (in black) by Three-Way ANOVA (Holm-Sidak). Data are represented as mean ± S.E.M.