Table 2.
Landmark diabetes prevention trials
| Study | Country | Years of study | Prediabetes phenotypes | Age of participants (in years) | Study arms (n) | Weight target | Mean follow-up (in years) | Risk reduction for diabetes (intervention versus control) |
|---|---|---|---|---|---|---|---|---|
| Chinese Da Qing (81) | China | 1986–1992 | IGT | ≥25 | Diet (130) Exercise (141) Diet and exercise (126) Control (133) |
No specific weight target | 6 | Diet (31.5%) Exercise (46%) Diet and exercise (42%) |
| Finnish DPS (108) | Finland | 1993–2001 | IGT | 40–65 | Diet and exercise (265) Control (257) |
>5% weight loss | 4 | Diet and exercise (58%) |
| American DPP (56) | United States | 1996–2001 | IGT and ADA-IFG | ≥25 | Diet and exercise (1,079) Metformin(1,073) Control (1,082) |
7% weight loss | 2.8 | Diet and exercise (58%) Metformin (31%) |
| Indian DPP (86) | India | IGT | 33–55 | Diet and exercise (133) Metformin (133) Diet, exercise, and metformin (136) Control (136) |
No specific target | 3 | Diet and exercise (28.5%) Metformin (26.4%) Diet, exercise, and metformin (28.2%) |
Abbreviations: DPP, Diabetes Prevention Program; DPS, Finnish Diabetes Prevention Study; IFG, impaired fasting glycemia; IGT, impaired glucose tolerance.