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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Mol Neurobiol. 2021 Jan 7;58(5):2019–2029. doi: 10.1007/s12035-020-02226-4

Fig. 4.

Fig. 4

Cisplatin-induced hearing loss in Lmo4 conditional knockout mice. a) Schematic illustration of the experimental design to analyze cisplatin-induced hearing loss. b) Assessment of ABRs indicated that cisplatin treatment induced a significantly higher shift in the hearing thresholds of Lmo4 conditional knockout mice when compared to that of wild-type littermates that express LMO4 in hair cells. ABRs recorded from the left ear of 5 mice are illustrated. The results are expressed as mean ± standard deviation, (**p<0.01). c) Assessment of DPOAEs indicated that cisplatin treatment significantly decreased the DPOAE amplitudes in Lmo4 conditional knockout mice when compared to that of wild-type littermates that express LMO4 in hair cells. DPOAEs recorded from the left ear of 3 mice are illustrated. The results are expressed as mean ± standard deviation (*p<0.05, **p<0.01, ***p<0.001).