Figure 1:

Schematic representation of the normal (left) and estrogenized (right) developing prostate gland that highlight essential morphogens and transcription factors (top) and steroid receptors (bottom) that coordinately regulate morphogenesis and differentiation. Relative gene expression levels are represented by type size. Dysregulation of steroid receptors and morphoregulatory gene expression following early estrogenic exposures results in stunted growth, structural rearrangements and aberrant cell differentiation. See text for details. Reproduced with permission from (57).