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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Mol Neurobiol. 2021 Jan 8;58(5):2215–2230. doi: 10.1007/s12035-020-02184-x

Fig. 8. Chronic cocaine dependence upregulated the expression of NLRP3 pathway mediators and microglial activation in human brains of cocaine addicts.

Fig. 8

Post mortem cortex brain tissues from chronic cocaine dependent addicts and non-cocaine using controls were analyzed for the expression of NLRP3 pathway mediators. The expression of NLRP3, ASC, Caspase-1 and IL-1β was increased in the brains of cocaine addicts compared with no-cocaine using controls (a – d). As shown in e & f, expression of the microglial markers Iba-1 and CD11b was also increased in the brains of cocaine abusers compared with no-cocaine using controls. N = 4 / group. Quantification of western blots is shown under each blot. Data are shown as mean±SEM and *p< 0.05