. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Cancer Prev Res (Phila). 2021 Jan 28;14(4):433–440. doi: 10.1158/1940-6207.CAPR-20-0448

Table 2:

Odds ratios for cancer risk for all ATM pathogenic variants

Cancer type	All ATM pathogenic variants
Cancer type	Odds ratio	95% CI	P-value
Breast - Ductal Invasive	2.03	1.89–2.19	<0.0001
Breast - DCIS	1.80	1.61–2.02	<0.0001
Breast – Lobular Invasive	0.94	0.74–1.20	0.6229
Breast - Male	1.72	1.08–2.75	0.0233
Ovarian	1.57	1.35–1.83	<0.0001
Colorectal	1.49	1.24–1.79	<0.0001
Endometrial	1.10	0.88–1.36	0.4079
Melanoma	1.46	1.18–1.81	0.0006
Prostate	2.58	1.93–3.44	<0.0001
Pancreatic	4.21	3.24–5.47	<0.0001
Gastric	2.97	1.66–5.31	0.0002

Note: Odds ratio are adjusted for personal (coded as binary, affected/unaffected, variables) and family (numeric counts weighted by degree of relation) cancer histories of breast (invasive, ductal, DCIS, and male), ovarian, colorectal, melanoma, gastric, pancreatic, prostate, endometrial, and colon (polyps), as well as age, sex and ancestry.