Comparative effectiveness of vedolizumab vs TNF antagonist therapy in UC for achieving steroid-free clinical remission and steroid-free deep remission. (A) Comparative effectiveness of vedolizumab vs TNF antagonist therapy for steroid-free clinical remission. (B) Comparative effectiveness of vedolizumab vs TNF antagonist therapy for steroid-free deep remission (steroid-free clinical + endoscopic remission). CI, confidence interval; IPW, inverse probability weighting; TNF antagonist, tumor necrosis factor antagonist (infliximab, adalimumab, golimumab); UC, ulcerative colitis. Analyses restricted to patients on steroids at baseline. Steroid-free deep remission was defined as achieving clinical remission, endoscopic remission, tapering off steroids, and no repeat steroid prescription for at least 4 weeks.