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. 2021 Apr 7;11:36. doi: 10.1186/s13550-021-00777-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a According to the lowest Akaike Information Criterion (AIC), the two-compartment model (2TCM, full line) fitted better the TACs (here striatum, circles) compared to the one-compartment model (1TCM, dashed line). b Logan graphical linear fit of striatal TAC (circles) with t* fixed at 60 min. c Dose dependent displacement of [¹⁸F]UCB-H at 90 min after radioligand injection by [¹⁹F]UCB-H at 80 µg/kg (red) and 5 mg/kg (blue). Slower brain penetrance of LEV (30 mg/kg, black) induced a slower displacement