Table 1. Pyruvate dehydrogenase kinases and related pathological conditions.
| Subtypes of PDK | Related symptoms | Reference |
|---|---|---|
| PDK1 | Human gallbladder cancer | [74] |
| Breast cancer | [113] | |
| Ovarian cancer | [114] | |
| Hypoxic tumors | [115] | |
| Neck squamous cell carcinoma | [75] | |
| Multiple myeloma | [116] | |
| Colorectal cancer | [117] | |
| Glioblastoma | [118] | |
| PDK2 | Ovarian cancer | [119] |
| Glioblastoma | [120] | |
| Type 2 diabetes | [121] | |
| Lung cancer | [84] | |
| PDK3 | Colon cancer | [87,88] |
| X-linked Charcot-Marie-Tooth neuropathy | [122] | |
| Lung cancer | [123] | |
| PDK4 | Type 2 diabetes | [121,124,125] |
| Hemochromatosis | [126] | |
| Glucocorticoid excess; e.g., Cushing syndrome | [5,127] | |
| Cardiac hypertrophy | [128] | |
| Statin induced myopathy | [129] | |
| Ovarian cancer | [119] | |
| Anoikis and tumor metastasis | [10] | |
| Vascular calcification | [68,69,130,131] | |
| Colon cancer | [91,132] | |
| Nonalcoholic steatohepatitis | [133] | |
| Prostate cancer | [134] |