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. 2021 Mar 25;12:621339. doi: 10.3389/fphar.2021.621339

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Copyright © 2021 Gu, Zhang, Li, Huang, Jiang, Chen, Chen, Jia, Zhang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Effect of FA on gut microbiota metabolite in ApoE^−/− mice. (A) The PLS-DA Scores plots in per group. (B) One-way ANOVA plots of metabolite among groups. The metabolite above the horizontal line had a difference among groups with p < 0.05. (C) The metabolites with VIP values >1.0 were regarded as important. Red and blue indicated increased and decreased levels, respectively. (D) The content of differential metabolites (acetate, leucine, butyrate, propionate, Cholate, valine, Glutamate and alanine) among groups (n = 4). ^# p < 0.05; as compared to the model group.