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. 2021 Mar 25;12:560903. doi: 10.3389/fphar.2021.560903

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Copyright © 2021 Ren, Wang, Huang, Xu, Weng and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the combination therapy on the mouse RCC xenograft model. Caki-1 tumor-bearing nude BALB/c mice were treated with a vehicle control, alternol, TRAIL, or combination. (A) Posttreatment changes in tumor volumes. (B) Posttreatment changes in tumor size. (C) Body weight changes in each group. (D) The indicated proteins were determined by western blot in tumors. Data are the mean ± SD of three independent experiments. *p < 0.05; **p < 0.01; p < 0.001, compared with control.