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. 2021 Mar 25;12:621164. doi: 10.3389/fimmu.2021.621164

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Copyright © 2021 Jiang, Lu and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The key innate immune genes of tree shrew are genetically close to Homo sapiens. (A), The variation of coding amino acid of STING gene in tree shrew (Tupaia belangeri chinensis), and Homo sapiens. (B–D), Phylogenetic tree of STING (B), TLR3 (C) and MDA5 (D) gene of T. belangeri, H. sapiens, Macaca mulatta, Sus scrofa and Mus. The phylogenetic tree was constructed using the Maximum Likelyhood phylogeny test. Bootstrap values were set for 1,000 repetitions. (E, F) Viral replication of DENV-3 in Vero (E) and BM-MSCs (F) cells. DENV-3 genomic RNA was tested from 0 to 96 h post-inoculation in culture supernatants of Vero cells and tupaia BM-MSCs.