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. 2021 Mar 25;12:621164. doi: 10.3389/fimmu.2021.621164

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Copyright © 2021 Jiang, Lu and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Viral RNA copies and H&E analysis in tissues of DENV-2 and DENV-3 infected tree shrew. (A) Genome RNA of DENV in the liver and brain. Circle dots represent the control group. 48 days post infection. High viral RNA copies were detected in the brain. The results from each group were compared using Student’s t test. *P <0.05. (B) Histopathology aspects of Tupaia chinensis brain tissue 48 days post infection of DENV-2 (DV2) and DENV-3 (DV3). DV2-II, a small number of inflammatory cells were seen locally near the ventricle in brain tissue (Black arrow) and local proliferation of arachnoid endothelial cells in brain tissue (Black arrow) were observed. The Blood vessel sleeve (Black arrow) and glial nodule (Blue arrow) were observed in brain tissue of DV2-SMI. DV3-II, glial nodules (Black arrow), individual vascular sleeves (Blue arrow) and proliferation of keratinocytes (Black arrow) in brain tissue were observed. DV3-SMI, hemorrhagic foci of brain tissue (Black arrow) and multiple glial nodules in brain tissue (Black arrow) were observed. *P <0.05.