. 2021 Mar 19;10(8):2924–2939. doi: 10.1002/cam4.3854

TABLE 4.

Correlation analysis between SOBP and marker genes of immune cells (TIMER)

Description	Gene markers	None		Purity
Description	Gene markers	R	p	R	p
CD8+ T cell	CD8A	−0.147	^*	−0.159	^*
CD8+ T cell	CD8B	0.011	0.842	0.016	0.807
T cell (general)	CD3D	−0.257	***	−0.311	***
	CD3E	−0.202	***	−0.260	***
	CD2	−0.217	***	−0.264	***
B cell	CD19	0.048	0.407	0.093	0.145
B cell	CD79A	−0.067	0.242	−0.046	0.473
Monocyte	CD86	−0.192	***	−0.271	***
Monocyte	CD115(CSF1R)	−0.084	0.146	−0.179	^**
TAM	CCL2	−0.178	^**	−0.209	***
	CD68	−0.137	^*	−0.212	***
	IL10	−0.032	0.574	−0.022	0.731
M1 Macrophage	INOS(NOS2)	0.199	***	0.203	^**
M1 Macrophage	IRF5	−0.021	0.715	−0.061	0.336
M2 Macrophage	COX2 (PTGS2)	0.149	^**	0.135	^*
	CD163	−0.076	0.188	−0.132	^*
	VSIG4	−0.135	^*	−0.204	^**
	MS4A4A	−0.092	0.109	−0.159	^*
Neutrophils	CD66b(CEACAM8)	0.163	^**	0.131	^*
	CD11b(ITGAM)	−0.092	0.109	−0.171	^**
	CCR7	−0.033	0.565	−0.073	0.250
Natural killer cell	KIR2DL1	−0.066	0.255	−0.040	0.531
	KIR2DL3	−0.228	***	−0.259	***
	KIR2DL4	−0.259	***	−0.285	***
	KIR3DL1	−0.130	^*	−0.147	^*
	KIR3DL2	−0.019	0.738	−0.037	0.563
	KIR3DL3	−0.149	^**	−0.150	^*
	KIR2DS4	−0.134	^*	−0.161	^*
Dendritic cell	HLA‐DPB1	−0.228	***	−0.259	***
	HLA‐DQB1	−0.195	***	−0.185	^**
	HLA‐DRA	−0.251	***	−0.249	***
	HLA‐DPA1	−0.237	***	−0.249	***
	BDCA−1(CD1C)	−0.060	0.297	−0.120	0.059
	BDCA−4(NRP1)	0.136	^*	0.087	0.169
	CD11c(ITGAX)	−0.081	0.157	−0.150	^*
Th1	T‐bet(TBX21)	−0.177	^**	−0.256	***
	STAT4	−0.023	0.693	−0.042	0.513
	STAT1	0.014	0.803	0.060	0.346
	IFN‐y(IFNG)	−0.173	^**	−0.160	^*
	TNF‐a(TNF)	−0.121	^*	−0.094	0.140
Th2	GATA3	−0.002	0.968	0.002	0.974
	STAT6	0.089	0.121	0.068	0.284
	STAT5A	−0.048	0.408	−0.121	0.057
	IL13	−0.072	0.210	−0.051	0.427
Tfh	BCL6	0.063	0.277	−0.007	0.908
Tfh	IL21	−0.054	0.345	−0.056	0.383
Th17	STAT3	0.063	0.273	0.021	0.746
Th17	IL17A	−0.071	0.216	−0.095	0.137
Treg	FOXP3	−0.107	0.063	−0.117	0.066
	CCR8	−0.165	^**	−0.156	^*
	STAT5B	0.326	***	0.263	***
	TGFβ(TGFB1)	0.061	0.289	−0.006	0.920
T cell exhaustion	PD−1(PDCD1)	−0.096	0.095	−0.115	0.069
	CTLA4	−0.165	^**	−0.170	^**
	LAG3	−0.148	^**	−0.161	^*
	TIM−3(HAVCR2)	−0.203	***	−0.292	***
	GZMB	−0.280	***	−0.291	***

TAM, tumor‐associated macrophage; R, Spearman rank correlation coefficient; None, correlation without adjustment. Purity, correlation adjusted by purity.

p < 0.05.

^**

p < 0.01.

^***

p < 0.001.