TABLE 2.
Summary relative risk for older vs. younger patients from random‐effects models by tumor outcome and after adjustment for confounders of the risk estimates
| No. of estimates | SRR | Lower 95% CI | Upper 95% CI | p‐value | I2 (%) | ||
|---|---|---|---|---|---|---|---|
| OS | Overall | 31 | 1.17 | 0.93 | 1.47 | 76 | |
| Crude | 20 | 0.88 | 0.71 | 1.09 | <0.01 | 35 | |
| Adjusted | 11 | 1.93 | 1.52 | 2.45 | 41 | ||
| DSS | Overall | 21 | 0.94 | 0.66 | 1.33 | 74 | |
| Crude | 12 | 0.67 | 0.45 | 1.00 | 0.01 | 63 | |
| Adjusted | 9 | 1.52 | 0.95 | 2.42 | 64 | ||
| DFS | Crude | 11 | 0.76 | 0.6 | 0.95 | 31 | |
| LRFS | Crude | 12 | 0.76 | 0.63 | 0.92 | 0 | |
| RRFS | Crude | 12 | 0.75 | 0.48 | 1.17 | 73 | |
| DRFS | Crude | 12 | 0.60 | 0.27 | 1.35 | 66 | |
P‐value from meta‐regression
SRR, summary risk estimate; CI, confidence interval; OS, overall survival; DSS, disease‐specific survival; DFS, disease‐free survival; LRFS, local recurrence‐free survival; RRFS, regional recurrence‐free survival; DRFS, distant recurrence‐free survival