Table 3.
Pharmacokinetic parameters of forsythin, M1 (aglycone), M2 (M1 sulfate), and M7 (M1 glucuronide) following administration of 800 mg forsythin capsules in 8 healthy subjects.
| Parameters | Forsythin | M1 | M2 | M7 |
|---|---|---|---|---|
| Cmax (ng/mL) | 65.9 ± 15.5 | 22.7 ± 19.8 | 5590 ± 2290 | 241 ± 89.5 |
| Tmax (h) | 1.50 (1.00–2.50) | 11.0 (6.00–12.0) | 11.0 (1.50–12.0) | 10.0 (1.50–12.0) |
| Cmax1 (ng/mL) | 59.9 ± 18.2 | 3.91 ± 1.41 | 1890 ± 562 | 102 ± 35.0 |
| Tmax1 (h) | 1.25 (0.50–2.50) | 0.875 (0.50–1.50) | 0.875 (0.50–1.50) | 0.75 (0.5–1.5) |
| Cmax2 (ng/mL) | 56.3 ± 22.7 | 19.8 ± 20.8 | 4275 ± 2965 | 235 ± 95.8 |
| Tmax2 (h) | 2.5 (1.5–8) | 7.00 (6.00–12.0) | 6.00 (2.00–12.0) | 9.00 (6.00–12.0) |
| AUC0–t (h·ng/mL) | 279 ± 80 | 222 ± 137 | 57,700 ± 19200 | 2820 ± 1140 |
| AUC0–∞ (h·ng/mL) | 283 ± 80 | 244 ± 134 | 59,400 ± 19700 | 3050 ± 1060 |
| t1/2 (h) | 1.83 ± 0.24 | 7.00 ± 2.29 | 5.74 ± 2.31 | 6.6 ± 3.55 |
| Vz/F (L) | 7920 ± 2110 | – | – | – |
| CL/F (L/h) | 3070 ± 1020 | – | – | – |