Figure 3.
Exposure-metabolites subnetworks identified by the GGMs inferred from the women FF metabolomics dataset. The subnetwork A represents associations of phenols and phthalates with metabolites involved in steroid hormone biosynthesis. The subnetwork B shows associations between 4-hydroxyacetophenone, PFOS and PFHxS and metabolites involved bile acids, arachidonic and vitamin D metabolism. Blue and red nodes represent endogenous metabolites and environmental chemicals, respectively. Plain and dashed edges connecting nodes represent positive partial correlations and negative partial correlations, respectively. Edges connecting nodes represent significant partial correlations at FDR < 10%.