Fig. 3.
Activated/effector-like phenotype of Foxp3+ Treg cells in Cd25Y129H mice. a–f Representative histograms (upper panels) and quantitative analysis (lower panels) of the MFIs of the indicated Treg surface markers on spleen CD4+Foxp3+ Treg cells from WT (filled circles) and Cd25Y129H (open circles) mice. Data were derived from at least three independent experiments with 5 mice per genotype. Percentages (left) and absolute cell numbers (right) of CD62L+ (g) and CD44+ (h) Treg cell populations in different organs of WT and Cd25Y129H mice. Data were derived from at least three independent experiments with 6–8 mice per genotype and are represented as the mean ± SD; ns not significant; *p < 0.05, **p < 0.01, ***p < 0.001; two-tailed unpaired Student’s t test