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. 2021 Jan 6;18(2):398–414. doi: 10.1038/s41423-020-00599-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Lack of autoimmune symptoms in aged Cd25^Y129H mice. a Weekly body weight monitoring of female (left) and male (right) WT (black line) and Cd25^Y129H (red line) mice. Data were derived from 6 to 12 mice per genotype and sex. b Percentages and absolute cell numbers of CD44^hi cells among CD4⁺ and CD8⁺ T cells from the pLNs (left) and spleen (right) of WT (filled circles) and Cd25^Y129H (open circles) mice. Data were derived from at least three independent experiments with 9–13 mice per genotype. c Representative immunofluorescence microscopy of the salivary glands, lacrimal glands, and pancreas of WT (top) and Cd25^Y129H mice (bottom) stained with the indicated antibodies. Scale bar, 500 μm. d Individual size (left) and number (right) of lymphoid infiltrates per section in the salivary glands, lacrimal glands, and pancreas of WT (filled circles) and Cd25^Y129H (open circles) mice. Data were derived from at least three independent experiments with 9–13 mice per genotype. a–d Organs were isolated from 35- to 40-week-old mice. Data are shown as the mean ± SD. ns not significant; *p < 0.05 (two-tailed unpaired Student’s t test)