Table 2.
Treatment-related adverse events in arm E.
| Adverse event | No. (%) |
|---|---|
| Any grade occurring in at least two patients — no. (%) | |
| Fatigue | 13 (57%) |
| Anemia | 12 (52%) |
| Thrombocytopenia | 11 (48%) |
| Nausea | 6 (26%) |
| Weight loss | 6 (26%) |
| Cough | 3 (13%) |
| Oral mucositis | 3 (13%) |
| Neuropathy | 3 (13%) |
| Vomiting | 2 (9%) |
| Diarrhea | 2 (9%) |
| Abdominal pain | 2 (9%) |
| Grade 3–5 occurring in at least one patient — no. (%) | |
| Hypertension (Grade 3) | 5 (22%) |
| Proteinuria (Grade 3) | 4 (17%) |
| HFS (Grade 3)a | 4 (17%) |
| Leukopenia (Grade 3) | 2 (9%) |
| Elevated ALT (Grade 4)a | 2 (9%) |
| Neutropenia (Grade 4) | 1 (4%) |
| Chest distress (Grade 3) | 1 (4%) |
| Decreased appetite (Grade 3) | 1 (4%) |
ALT, alanine aminotransferase; HFS, hand-foot syndrome.
aShown are the adverse events that caused discontinuation of drug usage.