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. 2021 Apr 7;11:7672. doi: 10.1038/s41598-021-87375-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of zoledronic acid on OTM with 21 days of tooth displacement in the experimental groups. (A) Macroscopic analysis by computed microtomography. The black arrow indicates the direction of the force on the compression side. (B) Bars represent mean ± SEM of 6 animals per group. (*) indicates difference when compared to the naive group (#) indicates difference when compared to the saline group. (§) indicates difference when compared to the ZA group (0.2) (ANOVA p < 0.001, Levene p = 0.001 and Games—Howell pos-hoc test).