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. 2020 Aug 7;42(2):230–241. doi: 10.1038/s41401-020-0490-7

Fig. 8. Illustration of the mechanism by which SIRT3 deficiency exacerbates diabetic cardiomyopathy.

Fig. 8

SIRT3 deficiency aggravated hyperglycemia-induced mitochondrial damage, increased ROS accumulation, promoted necroptosis and cell rupture, possibly activated the NLRP3 inflammasome, and finally exacerbated diabetic cardiomyopathy in the mice.