Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 25;8:644644. doi: 10.3389/fmolb.2021.644644

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Liao, Remington, May and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Representative conformation of PACAP-activated PAC1null receptor. (A) Structural alignment of PACAP-activated (red) and ligand-free (cyan) conformations. Ligand-free conformation is from our recent study(Liao et al., 2017) with only the 7TM shown. PACAP is shown in green cartoon and ECD is shown in surface representation. (B) Time evolution of average distance or pair distance of key charged/polar residues locating at the extracellular side, middle transmembrane, and intracellular side of the PAC1null receptor, which are displayed in (C) accordingly. Adaptive tempering period is in light orange strip background.