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. 2021 Mar 25;12:630210. doi: 10.3389/fphar.2021.630210

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Copyright © 2021 Zhou, Zou, Zhang, Wang, Yang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JPYS formula activates the Nrf2 signaling in the kidneys from CKD rats. (A) IHC staining of Nrf2 in the kidney (×200, scale bar = 100 μm). (B) Quantification ofNrf2 density. Nrf2-positive areas are indicated by arrows. (C) Representative western blots for Keap1, Nrf2, HO-1, and GAPDH protein expression in kidney tissue. (D) Quantitative analysis of Keap1/GAPDH. (E) Quantitative analysis of Nrf2/GAPDH. (F) Quantitative analysis of HO-1/GAPDH. Relative mRNA expression levels of Keap1 (G), HO-1 (H), and Nrf2 (I). All data are expressed as means ± SEM. *p < 0.05, **p < 0.01 vs. the sham group; #p < 0.05, ##p < 0.05 vs. CKD group.