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. 2021 Mar 25;12:624360. doi: 10.3389/fimmu.2021.624360

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Copyright © 2021 Zhang, Liu, Zhong, Zheng, Li, Guo, Zhang, Ran, Zhao, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased intestinal permeability and loss of epithelial barrier integrity in AIH patients. (A) The plasma concentrations of LPS, DLA and DAO in CTRL group (n=15), AIH-n group (n=39) and AIH-c group (n=29). (B) Expression of ZO-1 and Occludin in the colon were assessed by immunostaining. (C) The plasma concentration of zonulin in the three groups. (D) Representative immunostaining of ZO-1 and Occludin in Caco-2 cells. Scale bars: 50μm. The data were presented as means ± SD (Student’s t-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).