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. 2021 Mar 25;12:624360. doi: 10.3389/fimmu.2021.624360

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Copyright © 2021 Zhang, Liu, Zhong, Zheng, Li, Guo, Zhang, Ran, Zhao, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RIP3 signaling pathway regulates the expression of macrophage-related cytokines and chemokines in RAW264.7 cell lines. (A, B) Relative expression of RIP3 and MLKL was inhibited by GSK872. (C, D) Relative expression of TNF-α, IL-6, and IL-1β (C), CCL2 and CCR2(D) was down-regulated by GSK872. (E, F) Relative expression of RIP3 was inhibited by RIP3 siRNA and key cytokines such as TNF-α and IL-6 were detected and the relative intensity was quantified. (G, H) Relative expression of TNF-α, IL-6, and IL-1β (G), CCL2 and CCR2(H) was down-regulated by RIP3 siRNA. The data were presented as means ± SD of three independent experiments (Student’s t-test, *p < 0.05, **p < 0.01, ***p < 0.001, ns: p > 0.05).