Table 1.
HLA class II alleles of T1D organ donors and the numbers of T cells analyzed.
| Donor ID | HLA-DRB1* | DQA1-DQB1* | DPA1-DPB1* | Number of clonal T cells analyzed | Number of unique TCRs analyzed | Number of PPI-reactive TCRs |
|---|---|---|---|---|---|---|
| nPOD 69 | 04:01 (DR4) 07:01 (DR7) |
03:01-03:02 (DQ8) 02:01-02:02 (DQ2.2) |
01:03-03:01 01:03-04:01 (DP4) |
7 | 7 | 0 |
| nPOD 6323 | 03:01 (DR17 [DR3]) 04:02 (DR4) |
05:01-02:01 (DQ2.5) 03:01-03:02 (DQ8) |
01:03-04:01 (DP4) | 52 | 56 | 4 |
| nPOD 6342 | 04:01 (DR4) 01:01 (DR1) |
03:01-03:02 (DQ8) 01:01-05:01 (DQ5) |
01:03-04:01 (DP4) | 34 | 40 | 5 |
| nPOD 6414 | 03:01 (DR17 [DR3]) 09:01 (DR9) |
05:01-02:01 (DQ2.5) 03:03-02:02 (DQ2.3) |
01:03-04:01 (DP4) 01:04-15:01 |
34 | 40 | 4 |
| nPOD 6472 | 03:01 (DR17 [DR3]) 04:04 (DR4) |
05:01-02:01 (DQ2.5) 03:01-03:02 (DQ8) |
01:03-04:01 (DP4) 02:01-10:01 |
30 | 33 | 1 |
| nPOD 6367 | 04:01 (DR4) 07:01 (DR7) |
03:01-03:02 (DQ8) 02:01-02:02 (DQ2.2) |
01:03-02:01 06:01-11:01 |
9 | 11 | 0 |
*Nomenclatures in parentheses indicate HLA serotypes.