Table 2.
HLA class II alleles of T1D organ donors and the numbers of T cells analyzed.
| nPOD Donor | TCR ID | Peptide | Peptide Sequence | Region in Proinsulin | HLA*# |
|---|---|---|---|---|---|
| 6342 | 23.F7 | PPI:24-38 | AFVNQHLCGSHLVEA | B-chain | DRB1*01:01 (DR1) |
| 6342 | 23.G6 | PPI:29-43 | HLCGSHLVEALYLVC | B-chain | DPA1*01:03-DPB1*04:01 (DP4) |
| 6323 | 6.H9 | PPI:33-47 | SHLVEALYLVCGERG | B-chain | DQA1*03:01-DQB1*03:02 (DQ8) DQA1*05:01-DQB1*03:02 (DQ8-trans) |
| 6342 | 20.D11 | PPI:33-47 | SHLVEALYLVCGERG | B-chain | DQA1*03:01-DQB1*03:02 (DQ8) |
| 6342 | 23.G8 | PPI:36-50 | VEALYLVCGERGFFY | B-chain | DRB1*04:01 (DR4), DRB1*01:01 (DR1) |
| 6414 | 55.B3 | PPI:37-51 | EALYLVCGERGFFYT | B-chain | DRB1*09:01 (DR9) |
| 6414 | 56.B1 | PPI:40-54 | YLVCGERGFFYTPKT | B-chain |
DQA1*05:01-DQB1*02:01 (DQ2.5)
DQA1*05:01-DQB1*02:02 |
| 6342 | 19.A4 | PPI:55-69 | RREAEDLQVGQVELG | (RR) C-peptide | DQA1*03:01-DQB1*03:02 (DQ8) |
| 6414 | 55.C10 | PPI:58-72 | AEDLQVGQVELGGGP | C-peptide | DRB4*01:01 (DR53) |
| 6323 | 8.E3 | PPI:72-87 | PGAGSLQPLALEGSLQ | C-peptide |
DQA1*05:01-DQB1*03:02 (DQ8-trans)
DQA1*03:01-DQB1*03:02 (DQ8) |
| 6414 | 53.A4-1 | PPI:72-87 | PGAGSLQPLALEGSLQ | C-peptide |
DQA1*05:01-DQB1*02:01 (DQ2.5)
DQA1*05:01-DQB1*02:02 DQA1*03:03-DQB1*02:02 (DQ2.3) DQA1*03:03-DQB1*02:01 |
| 6323 | 6.G4 | PPI:86-100 | LQKRGIVEQCCTSIC | (B-KR) A-chain |
DQA1*05:01-DQB1*03:02 (DQ8-trans)
DQA1*03:01-DQB1*03:02 (DQ8) |
| 6472 | 95.A9-1 | PPI:87-101 | QKRGIVEQCCTSICS | (B-KR) A-chain | DRB1*04:04 (DR4) |
| 6323 | 6.H11 | PPI:94-108 | QCCTSICSLYQLENY | A-chain | DRB1*04:02 (DR4) |
*Nomenclatures in parentheses indicate HLA serotypes.
#HLA allele combinations recognized by the TCR most efficiently are shown in bold.