Fig. 5.

Chart about the effects of autophagy inhibition and gene silencing of TfR on DHA-induced cell death, when examined using MTT assay, showed that knockdown of TfR or inhibition of autophagy enhanced cell death due to DHA. Inhibitory effect of DHA on cell survival was expressed as percentage of inhibition ratio; bars represent mean ± standard deviation from three independent experiments. *p < 0.05 was statistically significant when compared to control cells. 3-MA: 3-methyladenine; DHA: dihydroartemisinin; MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay; siRNA: small interfering RNA; TfR: transferrin receptor