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. 2021 Apr 7;11:7633. doi: 10.1038/s41598-021-85797-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plot showing a weakly positive correlation of baseline cfDNA with baseline tumor burden. Tumor burden was evaluated by response evaluation criteria in solid tumors, version 1.1. cfDNA was quantified by QuantiDNA Direct cfDNA Test Kit (Diacarta. Inc., CA, USA) according to the manual both (A) at baseline and (B) post-chemotherapy. We selected those whose interval between cfDNA test and TB evaluation was within 7 days, so 80 cases were qualified (A) at baseline, and 47 cases were qualified (B) post-chemotherapy. A weakly positive correlation between TB and cfDNA was observed at baseline (N = 80, Pearson’s coefficient = 0.24; 95% CI 0.017–0.433; P = 0.03), while no significant correlation was found for post-chemotherapy (N = 47, Pearson’s coefficient = 0.124; 95% CI − 0.169 to 0.397; P = 0.4).