Figure 5.

Progression-free survival (PFS)/disease free survival (DFS) in subgroups by therapy regimen. Stratified analysis of Kaplan–Meier curves by therapy regimen (chemotherapy alone (N = 45), chemotherapy plus TKIs (N = 15), chemotherapy plus VEGFIs (N = 53), and chemotherapy plus ICIs (N = 41)) for comparisons of PFS/DFS between (A) high cfDNA Ratio and low cfDNA Ratio groups, (B) high cfDNA baseline and low cfDNA baseline groups, (C) high post-therapy cfDNA and low post-therapy cfDNA groups (cut-values were set as median value), respectively. PFS/DFS was assessed according to Response Evaluation Criteria in Solid Tumors, version 1.1 through investigators’ review, and tick marks represent data censored at the last time the patient was known to be alive and without disease progression.