TABLE 2.
Serum levels of the oxidative stress and inflammatory indices in mice.
| Group | T-SOD (U/mL) | CAT (U/mL) | MDA (mmol/L) | AGEs (pg/ml) | TNF-α (ng/L) | IL-6 (pg/ml) | IL-10 (pg/ml) |
|---|---|---|---|---|---|---|---|
| Normal | 93.72 ± 16.79b | 39.68 ± 5.20a | 11.38 ± 2.55b | 35.40 ± 7.15b | 238.87 ± 67.66c | 17.36 ± 5.53c | 320.38 ± 47.29a |
| Model | 50.59 ± 8.49c | 19.49 ± 4.65c | 30.48 ± 7.83a | 126.93 ± 12.80a | 534.70 ± 86.93a | 73.72 ± 9.09a | 136.85 ± 27.68c |
| VC | 86.65 ± 15.80b | 25.19 ± 4.31b | 25.90 ± 8.19a | 116.81 ± 14.22a | 309.10 ± 59.64b | 50.12 ± 8.02b | 141.07 ± 16.49c |
| NMN | 173.31 ± 13.56a | 33.09 ± 5.30b | 15.80 ± 3.26cd | 32.83 ± 7.38b | 253.23 ± 44.90bc | 19.21 ± 5.14c | 163.20 ± 40.08bc |
| L | 140.75 ± 13.01b | 35.90 ± 5.47ab | 21.61 ± 3.87bc | 37.16 ± 7.21b | 249.26 ± 39.85bc | 18.84 ± 5.07c | 170.25 ± 34.98bc |
| NMN + L | 186.04 ± 29.54a | 36.31 ± 4.51a | 13.33 ± 3.31b | 19.52 ± 3.25c | 216.96 ± 31.50c | 13.09 ± 3.94c | 187.30 ± 27.74b |
Values are mean ± standard deviation (N = 10/group). The difference in variance between the two groups was significant (p < 0.05).
a-cMean values with different letters in the same column are significantly different (p < 0.05) according to Duncan’s honestly significantly different test. VC: mice treated with vitamin C (300 mg/kg).
NMN, mice treated with nicotinamide mononucleotide (300 mg/kg); L, mice treated with L. fermentum TKSN041 (1.0 × 109 CFU/ml); NMN + L, mice treated with nicotinamide mononucleotide (300 mg/kg) and L. fermentum TKSN041 (1.0 × 109 CFU/ml); T-SOD, total superoxide dismutase; CAT, catalase; MDA, malondialdehyde; AGEs, advanced glycation end products; TNF-α, tumor necrosis factor α; IL-6, interleukin 6; IL-10, interleukin 10.