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. 2021 Mar 25;11:675442. doi: 10.3389/fonc.2021.675442

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Copyright © 2021 Shen, Zheng, Zhou, Tong, Xu, Gao, Zhang and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-671 suppresses EMT via targeting S100P. (A) The levels of S100P mRNA in PAAD cells transfected with miR-671 mimic or miR-671 inhibitor, respectively. (B) The activities of S100P 3′-UTR reporter containing WT or MUT miR-671 binding sites were determined using luciferase assay following co-transfection with miR-671 mimic or miR-671 inhibitor. (C) Western blotting analysis of the indicated proteins in PAAD cells transfected as indicated. (D, E) Cell invasion assay (left) and tumor sphere formation assay (right) in PaCa-2 cells transfected with (or without) miR-671 mimic, with (or without) S100P expression vector (D), and in AsPC-1 cells transfected with (or without) miR-671 inhibitor, with (or without) S100P siRNA (E). ***P < 0.001.