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Akita-PTGOEmice showed normalized gluconeogenesis and glycolysis in the liver.A, PEPCK mRNA expression, (B) PK mRNA expression, (C) representative western blot images of PEPCK, GK, and loading control, (D) PEPCK protein expression, (E) GK protein expression, (F) PGC-1α mRNA expression, and (G) hepatic lactate levels in Akita, Akita-PTGOE, and nondiabetic controls (n = 6–19 in all experiments). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.
