TABLE 2.

Representative inhibitors of SIAH2 and protein kinases that regulate SIAH2.

Target	Inhibitor	IC50	References
SIAH2	BI-107F7	20 μM	Shah et al., 2009
	BI-107F9	5–10 μM	Shah et al., 2009
	Menadione	5–10 μM	Feng et al., 2019
	Betulinic acid	0.1 μM	Stebbins et al., 2013
	Adapalene	0.1 μM	Stebbins et al., 2013
p38	SB203580	<1 μM	Young et al., 1997
	LY2228820	5.3–3.2 nM	Fisk et al., 2014; Cicenas et al., 2017
	SCIO-469	9–90 nM	Fisk et al., 2014; Cicenas et al., 2017
	BIRB-796	38–520 nM	Fisk et al., 2014; Cicenas et al., 2017
	PH-797804	26–102 nM	Fisk et al., 2014; Cicenas et al., 2017
	VX-745	10–220 nM	Fisk et al., 2014; Cicenas et al., 2017
HIPK2	TBID	0.33 μM	Yamada et al., 2009
DYRK2	Curcumin	5 nM	Nguyen et al., 2017; Jarhad et al., 2018
	BINDY	7.94 nM	Nguyen et al., 2017; Jarhad et al., 2018
	LDN192960	13 nM	Banerjee et al., 2019
CHK2	AZD7762	5 nM	Zabludoff et al., 2008
	NSC1095554	0.22–24 μM	Jobson et al., 2007; Jobson et al., 2009
	NSC744039	0.22–24 μM	Jobson et al., 2007; Jobson et al., 2009
	2-arylbenzimidazole	15 nM	Arienti et al., 2005
	VRX0466617	120 nM	Carlessi et al., 2007
	Isothiazole carboxamidine	0.09–0.46 μM	Larson et al., 2007
	CCT241533	3 nM	Anderson et al., 2011
Plk3	Poloxipan	3.2 μM	Kumar and Kim, 2015
SRC	Dasatinib	0.55 nM	Sen and Johnson, 2011; Levitzki, 2013
	Saracatinib	<4 nM	Sen and Johnson, 2011; Levitzki, 2013
	Bosutinib	<4 nM	Sen and Johnson, 2011; Levitzki, 2013