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. 2021 Apr 7;12(4):376. doi: 10.1038/s41419-021-03621-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The cell proliferation rate was evaluated in osteosarcoma cell lines after transfection by MTT assay. B The migration rate of cells was detected in osteosarcoma cell lines after transfection by wound-healing assay. C The migration rate of cells was detected in osteosarcoma cell lines after transfection by transwell assay. Magnification times: ×200. D The effects of MCM8 knockdown on cell apoptosis were examined by flow cytometry. E The expression levels of apoptosis-related proteins were analyzed in osteosarcoma cells with shMCM8. F The effects of MCM8 knockdown on cell cycle were determined by flow cytometry. Results were presented as mean ± SD. G The expression of Akt, P-Akt, CDK1, MAPK9, and CDK6 was detected by western blot in MNNG/HOS cells of shCtrl and shMCM8 groups. *P < 0.05, **P < 0.01, ***P < 0.001.