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. 2021 Apr 7;12(4):376. doi: 10.1038/s41419-021-03621-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The heatmap of DEGs identified by RNA-sequencing of cells treated with shCtrl (n = 3) or shMCM8 (n = 3). B Interaction network diagram between DEGs was analyzed by IPA. The expression of several most significantly differentially expressed genes identified by qRT-PCR (C) and western blot (D) in MNNG/HOS cells with shMCM8. E Co-IP assay was used to verify whether there was protein interaction between MCM8 and CTGF. Control: MNNG/HOS cells transfected with negative control lentivirus. MCM8-Flag: MNNG/HOS cells transfected with Flag tagged MCM8 overexpression lentivirus. The data are expressed as mean ± SD (n ≥ 3).